Synthesis, characterization, biological activity, molecular docking and thermal analysis of binuclear complexes

ABSTRACT. Because of their potential medical applications as antimicrobial medicines, metal-ligand complexes have sparked a lot attention. Synthesis and characterization various metal-diamine were the goals research detailed in this paper. As result, synthesis new binuclear ligand; N,N'-bis(3-carboxysalcylidene)-4-chloro-1,2-phenylenediamine (H4fsacph) which is derivative from condensation 3-formyl-2-hydroxybenzoic acid 4-chlorobenzene-1,2-diamine has been performed. The synthesized ligand formed mononuclear complex with Cu(II). Cu(II) was used to form binary nuclear some metal ions, like Cr(III), Mn(II), Fe(III), Ru(III), Pd(II) La(III) ions. Elemental analysis, IR, UV-Visible, thermal analyzes characterize complexes. interaction receptors Candida albicans SARS-CoV-2 predicted using molecular docking. Toward bacteria fungi showing predominant activity against all verified antibacterial complexes, while they almost no bacteria. All compounds shown antifungal activities, but showed better activities compared original ligands, especially zinc(II) above results suggest that both ligands be explored active pharmaceutical agents.
 
 KEY WORDS: Molecular structure, Metal docking, Antimicrobial, SARS-CoV-2, Antifungal
 Bull. Chem. Soc. Ethiop. 2022, 36(4), 843-858. DOI: https://dx.doi.org/10.4314/bcse.v36i4.10